He was one of many who studied with the celebrated master Simon Vouet, who strongly influenced French painting of the early 17th century.
In 1648, Corneille was one of the founders of the French Royal Academy of Painting and Sculpture and was elected as one of the original twelve elders in charge of its running.
He was an excellent colorist—in this more Venetian than French—and his early style resembled that of Simon Vouet; later his work had all the merits and all the faults of the post-Raphaelite, or decadent, "sweet", school of Italian art, showing the far-reaching influence of the Carracci.
He was long employed in the decoration of churches in Paris, his masterpiece being the celebrated "St. Paul and St. Barnabas at Lystra", painted for the Cathedral of Notre-Dame.
Notable examples are the "Murder of the Innocents", after Raphael, and the "Virgin Suckling the Infant Jesus", after Lodovico Carracci.