[1] He was hired by John Jacob Astor's Pacific Fur Company in 1810 and sailed from New York City aboard the Tonquin.
[2] Laframboise and the rest of the crew and passengers arrived at the mouth of the Columbia River in 1811 where they established Fort Astoria.
[2] In 1821, the NWC was merged into the Hudson's Bay Company (HBC) and he stayed on as an interpreter and as a postmaster in their Columbia District.
[2][3] During his employment with the HBC, Laframboise participated and often led many expeditions through the southern Oregon Country to Mexican-owned Alta California.
[2] However, Laframboise stayed with the company and helped restore the health of Hall J. Kelley when he arrived at the fort in 1834 with Ewing Young.
[6] By 1852 he had settled a Donation Land Claim north of his original property and was operating a ferry across the Willamette River to Champoeg, connecting to the Champoeg-Salem Road.