Michele Bonelli, Cardinal Alessandrino (25 November 1541– 28 March 1598) was an Italian senior papal diplomat with a distinguished career that spanned two decades from 1571.

He studied at the Collegio Germanico and was a professor of theology at the University of Perugia before being recalled to Rome by his great-uncle, Pius V. He was created cardinal priest in the consistory of 6 March 1566; received the red hat and the titulus of Santa Maria sopra Minerva on 20 March and was entered with his father as a noble of Alessandria the same year; he conditioned his promotion on permission to continue wearing his Dominican habit.

As papal Rome was expanding, he took the initiative of developing a new quarter erected above the ancient imperial fora, laying out streets —of which via Alessandrina commemorates his title— which had come to be divided among the monasteries of S.Basilio, S.Adriano and SS.Cosma e Damiano, and planted in orchards.

The question of his advance notice of the imminent Saint Bartholomew's Day Massacre beginning the following 24 August has been discussed among historians and emphatically denied in the Catholic Encyclopedia [1].

He died in Rome the following year after a brief illness, and was buried in his Dominican church of Santa Maria sopra Minerva, where his tomb sculpture of Prudence is by Stefano Maderno.