Michele Jeanne Sison (born May 27, 1959)[1] is an American diplomat and career member of the Senior Foreign Service who had served as the assistant secretary of state for international organization affairs.

She also served at the U.S. missions in Abidjan, Côte d'Ivoire (1993–1996); Douala, Cameroon (1991–1993); Cotonou, Benin (1988–1991); Lomé, Togo (1984–1988); and Port-au-Prince, Haiti (1982–1984), as well as in Washington.

Prior to her appointment to the UAE, she served as Principal Deputy Assistant Secretary in the Bureau of South Asian Affairs, charged with providing broad policy oversight of U.S. relations with Pakistan, Afghanistan, Bangladesh, India, Nepal, and Sri Lanka.

[8] Among the major issues facing her in her role were navigating a response by the United Nations to victims of a cholera epidemic the organization started in October 2010.

She was also confronted with the U.S. government's decision on whether or not to extend Temporary Protected Status to Haitian immigrants who were in the U.S. at the time of the massive earthquake in Port-au-Prince in January 2010.

[10] On April 15, 2021, Sison was nominated by President Biden to serve as Assistant Secretary of State for International Organization Affairs.