Michele Pennisi (born 23 November 1946) is an Italian Archbishop of the Catholic Church in Sicily, and a noted opponent of the Sicilian Mafia.

He was ordained as a priest on 9 September 1972 by Bishop Carmelo Canzonieri,[3] after studying at the prestigious Almo Collegio Capranica in Rome.

On 28 April 2022 Pope Francis accepted Pennisi's letter of resignation as archbishop of the Archdiocese of Monreale, appointing Gualtiero Isacchi to replace him on the same day.

In 2007 he refused to allow a cathedral funeral service for convicted mafia chief Daniele Emmanuello, who had been killed during a shoot-out with police.

[5] On 17 March 2017, Pennisi again made news headlines for opposing the Sicilian Mafia, when he issued a blanket ban on known mafiosi becoming Godfathers to children within his diocese, stating that the application of the title to organised criminals could be an attempt to legitimise their crime through association with religion.