Her maternal great-grandfather Rodolfo Cohn was of Ashkenazi Jewish descent and immigrated to the Dominican Republic after surviving the Holocaust.
In 2020, she entered the casting of Miss Universe Puerto Rico 2020, however, due to the COVID-19 pandemic, the pageant was cancelled and the 2019 edition first Runner-Up Estefanía Soto was designated to represented Puerto Rico at the 2020 Miss Universe pageant as a result.
Colón later competed at Miss Universe Puerto Rico 2021, where she became the first representative from Loíza to win the title.
She is the first woman of predominantly African heritage to represent the island at Miss Universe.
This was the first time Puerto Rico placed four consecutive years, effectively ending the island's "three placement curse" at Miss Universe.