[citation needed] Holmes' first acting role was in the ITV soap The Practice as Susan Turner the receptionist.
[2] Originally she was given a part as an extra, but after pestering the producers at Granada with multiple phone calls, she was given an audition for Susan which was successful.
[1] Holmes played Yvonne Sparrow in the first three series of Goodnight Sweetheart,[1] and Maggie Coles in Firm Friends.
[1] In 2001, she played Connie Harper in Merseybeat,[1] and guest starred in the BBC One school drama, Waterloo Road as Lindsey Woodham.
[1] She played Theresa in the 2008 series of Shameless[1] and DC Barbara Maddox in the 2009 production of Lynda La Plante's ITV crime drama Above Suspicion.