The 22nd district was created by the 1850 Michigan Constitution, as the 1835 constitution only permitted a maximum of eight senate districts.

[2][3] It has been represented by Republican Lana Theis since 2019, succeeding fellow Republican Joe Hune.

[4] District 22 encompasses all of Livingston County, as well as part of Genesee, Ingham, and Shiawassee counties.

[5] District 22, as dictated by the 2011 Apportionment Plan, covered all of Livingston County and most of western Washtenaw County in exurban Detroit, including the communities of Brighton, Howell, Fowlerville, Whitmore Lake, Chelsea, Dexter, Brighton Township, Genoa Township, Green Oak Township, Hamburg Township, Hartland Township, Oceola Township, Tyrone Township, Marion Township, and Scio Township.

It overlapped with the 42nd, 47th, and 52nd districts of the Michigan House of Representatives.