The school competes in the Big Ten Conference in Division I of the National Collegiate Athletic Association (NCAA).

The Wolverines play their home games in Ann Arbor, primarily at Michigan Stadium with the indoor Oosterbaan Field House as a secondary option.

Prior to the establishment of its varsity program, women's lacrosse was a club sport at the University of Michigan.

In May 2011, the most pressing priorities for the new women's program were the search for its first head coach and its application for membership in the American Lacrosse Conference, which counted among its members other Big Ten schools such as Northwestern, Ohio State, and Penn State, as well as more distant institutions such as Florida, Johns Hopkins, and Vanderbilt.

[3] In 2014, Michigan played its inaugural varsity season as a member of the American Lacrosse Conference under head coach Jennifer Ulehla.