[2] Decimated by the 1906 earthquake and fire, the entire neighborhood was quickly rebuilt and for decades served as vibrant portion of the Market Street corridor.

Noted columnist Herb Caen referred to the neighborhood as 'le grand pissoir' because of the amount of public urination, defecation, and vagrancy due to a consolidation and expansion of homeless social services in the area, starting in the mid-1980s.

[6] Past initiatives such as sponsored street murals have had little effect in revitalizing the neighborhood and in 2011 the city government turned to tax incentives to encourage businesses to move to the area.

[18] Equally transformative, and often attributed to the new density of tech headquarters in Mid-Market, has been the concurrent increase of residential buildings, most notably high-rise apartments and condominium towers.

Like the rest of downtown San Francisco, Mid-Market was hit badly by the COVID-19 pandemic in 2020 and the subsequent shift to remote work.