The league is headed by the Premier Division which is at level eleven of the English football league system and member clubs are based in East Sussex, West Sussex and south-eastern Surrey.

Current sponsors are Gray Hooper Holt LLP and the league is currently known as the Gray Hooper Holt LLP Mid Sussex League.

The league was founded in 1900, made up of seven founder clubs: Ardingly, Burgess Hill, Crawley, Cuckfield, Haywards Heath, Hurstpierpoint and Three Bridges.

In 1903 a second division was formed and the league was accepting membership from clubs based on the south coast.

In 2002 the league took over management of the Mid Sussex Football Association Senior and Junior Charity Cups following the disbandment of the Mid Sussex Football Association.