The film deals with complex issues such as gay and lesbian related topics, the lower-middle class of Mexico City, and the lives of many people.

The story is told from three perspectives: Don Ru (Ernesto Gómez Cruz), the owner of a cantina where most of the men in the story gather to drink and play dominoes, Alma (Salma Hayek), the beautiful girl of the neighborhood who dreams of passion, and Susanita (Margarita Sanz who won an Ariel Award for this role), the owner of the apartment complex where Alma and many of the other characters live.

Pan's Labyrinth and El Callejón de los Milagros were named as the best Mexican films by IMDb and Entertainment Weekly.

[1][2] The lives of the inhabitants of El Callejón de los Milagros, in downtown Mexico City, are as closely knitted as the threads of a rug.

Fifty-something Don Ru owns a small "cantina" where all the men spend afternoons playing domino.