Middelkerke (Dutch pronunciation: [ˈmɪdəlˌkɛrkə]) is a municipality located in the Belgian province of West Flanders, on the North Sea, west of Ostend.

The municipality comprises the villages of Leffinge, Lombardsijde, Mannekensvere, Middelkerke proper, Schore, Sint-Pieters-Kapelle, Slijpe, Westende and Wilskerke.

The total area is 75.65 km2 which gives a population density of 236 inhabitants per km2.

In 1902, Middelkerke became the world's first municipality to have their drinking water disinfected by continuous chlorination.

[2] The Noordzeecross is a February cyclo-cross race held in Middelkerke, which is part of the Superprestige.