Middle Claydon is a village and civil parish in Buckinghamshire, England.

Administratively, the parish is within the remit of Buckinghamshire Council, the unitary authority for most of the county.

The toponym "Claydon" is derived from the Old English for "clay hill".

The Domesday Book of 1086 records the Claydon area as Claindone.

The house was the home of Sir Edmund Verney, an English Civil War Royalist,[3] and of Florence Nightingale.