Middle Creek High School is located at 123 Middle Creek Park Avenue of Cary, North Carolina, with a mailing address of Apex.

[4] However, the previous year, Athens Drive High School used it while it was being remodeled.

[4] The school opened with juniors and seniors, adding freshmen and sophomores the next year.

[2] The student body is 58.7% White, 21.2% Hispanic, 14.5% Black, 3% two or more races, 2.3% Asian, .2% American Indian, and .1% Hawaiian/Pacific Islander—for a total minority population of 41.3%.

[7] Juniors and seniors with a qualifying GPA can apply to join the National Honor Society.

Middle Creek High School has the following co-ed sports teams: varsity cheerleading, junior varsity cheerleading, cross country, indoor track, swim, and track.

[11] In 2013, the first class was inducted into the Middle Creek School Athletic Hall of Fame.