Early references to the game in London or Middlesex are often interchangeable and sometimes it is not clear if a particular team represents the city or the county.

[7] The earliest known match in Middlesex took place at Lamb's Conduit Fields in Holborn on 3 July 1707 involving teams from London and Croydon.

[7] The earliest known reference to a team called Middlesex is on 5 August 1728 when it played London Cricket Club "in the fields behind the Woolpack, in Islington, near Sadlers Wells, for £50 a side".

Middlesex played at Lillie Bridge Grounds from 1869 before leaving in 1872 due to the poor quality of the turf.

The club has produced several noted players, particularly the great batsmen Patsy Hendren, Bill Edrich and Denis Compton.

Don Bradman gave him the chance to score the 10 runs he needed in the Australian tour match with Middlesex by declaring his team's innings early.

They both passed Tom Hayward's 1906 record of 3,518 runs in a season with Compton making 3,816 at 90.86 and Edrich 3,539 at 80.43 with a dozen centuries.

The following season Compton and Edrich made their record unbeaten stand of 424 for the 3rd wicket against Somerset at Lords.

In the 4-Day version of the game, the club finished 3rd of the nine teams in Division 2 of the Liverpool Victoria County Championship, narrowly missing out on promotion.

The victory is also made historic as Middlesex became the first County Cricket Club to gain entry to both the Twenty20 Champions League and the Stanford Super Series.

And in a copy of their final standings from the previous season, Middlesex both failed to make it past the group stage in the Friends Provident Trophy and finished in 3rd place in the County Championship Division Two, again missing out on promotion by just one position.

In 2022 they secured promotion back to the top flight of the County Championship on the penultimate day of the season by finishing runners up to Nottinghamshire in Division two.