Middleton is an unincorporated community in Columbiana County, in the U.S. state of Ohio.
Middleton was among the first settlements made in Fairfield Township.
[1] A variant name of Middleton was Mosk.
[2] The Mosk post office was established in 1882, and remained in operation until 1902.
This Columbiana County, Ohio state location article is a stub.