[1] The site of the shopping centre was originally terraced streets that were demolished in the late 1960s.

In 2011 it was announced that the bosses at Middleton Grange are planning a rebrand, a facelift and a major push to bring in more business with a £2 million investment which see the 1960s mosaic tile effect outside the shopping centre replaced and modernised, the sea blue colour scheme inside will be replaced with a battleship grey colour scheme, the signs will be replaced with new signs and BHS announced they will be opening a new two floor 35,000 sq ft (3,300 m2) department store with a cafe in the old Woolworths store in September 2011.

The four anchor tenants are Marks & Spencer (until 2015), BHS, Wilko and Primark, There was fifth anchor tenant, The Co-operative Home Store and it closed in October 2011 leaving the large unit empty, the Eugene's Cafe at the bottom of the unit stayed open but closed in September 2012.

Middleton Grange was originally built to replace the old town centre located around Lynn Street.

As of October 2023, stores include Primark, Sports Direct, Iceland, Boots, Poundland and Ecigwizard.