Part of the Middleton-Cross Plains School District, the school serves more than 2,000 students in grades 9 to 12 from the Middleton and Cross Plains areas.

The MHS marching band was invited to perform in London in the 2011 and 2015 New Year's Day Parade.

[6] Wisconsin School Music Association (WSMA) State Marching Band competition: [7] (*Fall 2020 sports competed in Spring 2021 due to COVID-19) Middleton High School competes in the National Science Bowl, an academic competition ran by the United States Department of Energy.

The team was founded by a member of the Class of 2021, David Jiang.

In recent years, Middleton High School's Science Bowl team has achieved notable success.