It is situated approximately 4 miles (6.4 km) south east of Darlington.

[1] The village and neighbouring Middleton St George, unlike other places of the name, is not from Old English middel "middle" and tun "farm".

Middleton One Row falls within the Sedgefield parliamentary constituency which is under the control of the Conservative Party.

The current Member of Parliament, since the 2019 general election, is Paul Howell.

[3] The village contains a pub and restaurant called The Devonport and a former church, St Laurence's was owned by the Church of England and dated back to 1871, however it was officially closed in 2012 after structural difficulties and high repair costs,[4] it has now been converted into a luxury home.