The U.S. Route 301 toll road is just west and north of Middletown, serving the Chesapeake Bay Bridge to the southwest.

DE 71 passes north–south through Middletown on Broad Street and heads north to the Summit Bridge and south to Townsend and U.S. Route 13.

Delaware Route 15, a rural road, is concurrent with DE 299 at Middletown, allowing access to Dover and Smyrna.

DART First State serves Middletown along the Route 46 bus, which runs between a park and ride in Odessa and the Newark Transit Hub in Newark, passing through Middletown and serving the Amazon fulfillment center.

The Route 37 bus provides rush hour weekday and Saturday service between the Amazon fulfillment center in Middletown and Wilmington via the Christiana Mall.

[16] Public education in Middletown is provided by the Appoquinimink School District,[17] which has recently[when?]

Population in 2012: 19,483 White alone - 10,804 (58.4%) Black alone - 4,863 (26.3%) Hispanic - 1,319 (7.1%) Asian alone - 940 (5.1%) Two or more races - 491 (2.7%) American Indian alone - 29 (0.2%) Other race alone - 31 (0.2%) •Native Hawaiian and Other Pacific Islander alone - 18 (0.10%)[21] There were 2,298 households, out of which 41.3% had children under the age of 18 living with them, 48.5% were married couples living together, 18.1% had a female householder with no husband present, and 29.0% were non-families.

Recent annexations of land have stimulated Middletown's growth; it is known as the fastest growing area in Delaware.

[5] Many affluent housing developments surround the town's center, especially to its north, attracting, among others, commuters from Wilmington, and even Philadelphia.

National retail and food chain stores have opened locations in the area, with significant growth along the U.S. 301 corridor.

Middletown is home to the Olde Tyme Peach Festival, an annual tradition that attracts tens of thousands of visitors each August.

Big Ball Marathon, an annual Labor Day event that benefits local charities.

The marathon runs 24 hours straight where people of all ages come out to play baseball on previously registered teams with an oversized softball, giving it the name "Big Ball".

As opposed to the Mummers, which is judged seriously, the Hummers dress up and make fun of all the popular news headlines, political, celebrity, and local happenings of the year.

The episode of The West Wing entitled "Two Cathedrals" (#44) was partly filmed at St. Andrew's School.