Middletown Springs is the primary village and a census-designated place (CDP) in the town of Middletown Springs, Rutland County, Vermont, United States.

The CDP is in western Rutland County, at the geographic center of the town of Middletown Springs.

Vermont Route 133 leads south from the village center 11 miles (18 km) to Pawlet.

Middletown Springs is within the Taconic Mountains, in the valley of the Poultney River, which forms the southern edge of the CDP.

The river flows west and north to the south end of Lake Champlain on the Vermont/New York border.