[2] The county is so named for being halfway (midway) between Fort Worth and El Paso on the Texas and Pacific Railway.

[3] The Spraberry Trend, the third-largest oil field in the United States by remaining reserves, underlies much of the county.

[11] Oil and gas data from the Texas Railroad Commission reports 6,602 currently producing wells as of September 2020.

[12] Midland County was one of the first areas of Texas to turn Republican, beginning with native son Dwight D. Eisenhower's campaign for the presidency in 1952.

The last Democratic presidential candidate to win the county was Harry Truman in 1948.

[13] Even in the presidential election of 1964 in which the incumbent president, Texan Democrat Lyndon B. Johnson, won a national landslide victory, it gave 57.8% of its ballots to Republican presidential candidate and Arizona native Barry Goldwater.

Midland County is located in Texas's 11th congressional district, represented by Republican August Pfluger.