The film follows a photographer who attempts to track down a serial killer dubbed the "Subway Butcher", and discovers more than he bargained for under the city streets.

The film was directed by Ryuhei Kitamura, and stars Bradley Cooper, Leslie Bibb, Brooke Shields, Roger Bart, Ted Raimi and Vinnie Jones.

Producer Joe Daley, a long-time friend of Buhler's, brought the two writers together and helped develop the script, along with producers Anthony DiBlasi and Jorge Saralegui, for their and Clive Barker's production company Midnight Picture Show, which was responsible for Book of Blood, the next film adaptation from the anthology of short stories that spawned The Midnight Meat Train.

The true purpose of the abandoned station is revealed as reptilian creatures enter the car and start eating the bodies of the murdered passengers.

Detective Hadley hands the train schedule to the new butcher, who wears a ring with the symbol of the group that feeds the creatures.

The "official" soundtrack from Lakeshore Records (only containing two remixes of the separately available actual film score) was produced and remixed by Justin Lassen and includes the bands and artists Iconcrash, Breaking The Jar, Blind Divine, Manakin Moon, Three Dot Revelation, Apocalyptica, Slvtn, Alu, Robert Williamson, Johannes Kobilke, Second Coming, Illusion of Order, Jason Hayes, Gerard K Marino, Penetrator, and Digital Dirt Heads.

This is all about ego, and though I mourn the fact that The Midnight Meat Train was never given its chance in theaters, it's a beautifully stylish, scary movie, and it isn't going anywhere.

The website's consensus reads: "A creative and energetic adaptation of a Clive Barker short story, with enough scares and thrills to be a potential cult classic.

"[16] Jenni Miller of Première gave the film a score of 3/5 and wrote, "While it's difficult to make a short story into a feature length film, and Midnight definitely has its hiccups, director Ryuhei Kitamura's slick direction and Barker's grotesque details make it stand out from today's slew of remakes and sequels.

"[17] Luke Y. Thompson of LA Weekly found the film's plot weak, but had an otherwise positive response to it, calling it "worth the trip" with an ending that was "so totally nuts, you've gotta admire the cojones behind it.

"[18] Kaleem Aftab of The National criticized the film's story and "cartoonish" special effects, but admitted, "Nonetheless, there is a sprightly energy to the proceedings and a neat twist that makes this mindless fun something of a guilty pleasure.

"[21] The Midnight Meat Train was labeled a "fan film" by Tim Cogshell of Boxoffice Pro, who gave it a score of 2½ out of 5 and wrote, "It’s intense, perhaps, beyond reason.

"[22] Phelim O'Neill, in a review written for The Guardian, offered mild praise to the film's "unrestrained attitude to gore" and visuals, but lambasted its "rudimentary characterisation and tired jump/scare tactics" and ultimately awarded The Midnight Meat Train a grade of 2/5.

[23] Chris Willman of Entertainment Weekly was dismissive of The Midnight Meat Train, giving it a "D" grade and writing, "Jones is a terrifically imposing villain as he slays and flays late-night subway commuters—but the gorefest shifts from a suspenseful '80s slasher template to laughable fantasy/conspiracy mythology, culminating in a finale that redefines train wreck.