Download coordinates as: Midōsuji (御堂筋, Midō-suji) Avenue is the primary main street in central Osaka, Japan.

It runs north-south, passing Umeda, Nakanoshima, Shinsaibashi, Dōtonbori, Ame-mura, and Namba districts.

Midōsuji becomes the Shinmido-suji in Kita-ku, Osaka, running concurrently with Japan National Route 423.

Midōsuji was built in the Taishō period, widening an existing north-south street and extending it to run all the way to Umeda in the north and Namba in the south.

Today Midōsuji is an ultra high-class shopping street, housing clothing stores by such brands as Louis Vuitton, Chanel, major hotels, and even an Apple flagship.