The academy has produced multiple Danish national team players, such as Simon Kjær, Joachim Andersen, and Rasmus Kristensen.

FC Midtjylland was founded by Johnny Rune, a carpenter and owner of a private business in the wood-supply industry, and Steen Hessel, an authorized Mercedes-Benz dealer.

At least ten years had passed with the two clubs being unable to agree on a merger, but on 6 April 1999, a deal was finalised and announced at a press conference the next day.

In July 2014, Matthew Benham (owner of English club Brentford) became the majority shareholder of Midtjylland's parent company FCM Holding.

[7] Midtjylland have built a reputation of finding and developing promising talents, and have a highly regarded youth academy.

[8] In July 2004, Midtjylland was the first Danish club to establish their own football academy, similar to that of French side Nantes.

[14] Other notable sales of academy products include Pione Sisto to Celta Vigo, Rasmus Nissen to Ajax, Andreas Poulsen to Borussia Mönchengladbach and Mikkel Duelund to Dynamo Kyiv.

On 22 June 2022, the club started an expansion of MCH Arena that would add a new hospitality lounge and 11 new VIP boxes.

[15] It was founded in the beginning of August 1999, as the official fanclub of Ikast FS 1993 "Yellow Flames" changed their name at an extraordinary general meeting.

In 2016 Midtjylland reached the Round of 32 of the 2015–16 UEFA Europa League, where they achieved a 2–1 home victory over Manchester United but would end up losing 6–3 on aggregate following the second leg.