This service grew to establish a small hub at Chicago Midway International Airport by adding flights to Philadelphia, Boston, Allentown, Washington D.C., Orlando, Tampa, Dallas/Ft.

Due to competition and limited gate space, Midway Airlines moved to Durham, North Carolina, and set up a hub at Raleigh-Durham International Airport (RDU) in early 1995.

At the height of its operations, Midway offered almost 200 flights daily from RDU to 33 destinations on the East Coast, and was used by many passengers travelling between the Northeast and Southeast.

The first was Great Lakes Aviation flying Beechcraft 1900 and Embraer 120 Brasilias from 1995 through 1997 followed by Corporate Airlines, which operated British Aerospace BAe Jetstream 31 aircraft.

Following $12.5 million in financial infusion from the US federal government, Midway resumed service using their fleet of 12 Boeing 737-700 aircraft from RDU under its own livery on December 19, 2001.

At that time, they commenced operations as US Airways Express, with limited service offered from hubs in both RDU and Washington Reagan National Airport (DCA).

It finally ceased operations on October 30, 2003, through a Chapter 7 bankruptcy when it was unable to acquire enough capital to stay afloat despite a private equity firm's infusions during the course of Midway's history.