When the Midwest Collegiate Conference was originally formed in 1988, it consisted of six Roman Catholic colleges and universities situated across the Midwestern United States.

The following year, Clarke University left the MCC to participate in NCAA Division III athletics.

Members Ashford University and Waldorf College were voted out of the conference on May 17, 2011, with effect at the end of the 2011–12 season.

[1] On October 14, 2011, Iowa Wesleyan College announced they would join National Collegiate Athletic Association's Division III.

[3] On February 5, 2015, AIB College of Business announced they would end their athletic programs as the school prepared to be coming a part of the University of Iowa.