Twenty-four players who have won the MVP Award also won the Midwest League Top MLB Prospect Award (formerly the Prospect of the Year Award) in the same season: Willie Wilson (1975), Paul Molitor (1977), Bill Foley (1978), Dave Stockstill (1979), Von Hayes (1980), Luis Medina (1986), Tom Redington (1989), Reggie Sanders (1990), Salomón Torres (1991), Steve Gibralter (1992), Pablo Ozuna (1998), Albert Pujols (2000), Adrián González (2001), Prince Fielder (2003), Brian Dopirak (2004), Carlos González (2005), Ben Revere (2008), Dee Strange-Gordon (2009), Mike Trout (2010), Rymer Liriano (2011), Byron Buxton (2013), Eloy Jiménez (2016), Bo Bichette (2017), and Andy Pages (2021).
In 2021, the Midwest League established a Pitcher of the Year Award.
[2] Nine players from the Cedar Rapids Kernels have been selected for the MVP Award, more than any other team in the league, followed by the Beloit Sky Carp, Burlington Bees, Kane County Cougars, Lansing Lugnuts, and Waterloo Indians (4); the Dubuque Packers, Great Lakes Loons, Peoria Chiefs, Springfield Cardinals, and West Michigan Whitecaps (3); the South Bend Cubs (2); and the Clinton Giants, Decatur Commodores, Fort Wayne TinCaps, Kenosha Twins, Kokomo Dodgers, Lake County Captains, Madison Muskies, Michigan Battle Cats, Midwest Dodgers, Rockford Royals, and Wausau Timbers (1).
Six players from the St. Louis Cardinals Major League Baseball (MLB) organization have won the award, more than any other, followed by the Cleveland Guardians, Los Angeles Dodgers, Milwaukee Brewers, and Minnesota Twins organizations (5); the Detroit Tigers organization (4); the Chicago Cubs, Cincinnati Reds, San Francisco Giants, and Toronto Blue Jays organizations (2); the Arizona Diamondbacks, Kansas City Royals, Los Angeles Angels, Miami Marlins, and Oakland Athletics organizations (2); and the Atlanta Braves, Chicago White Sox, Houston Astros, Pittsburgh Pirates, and San Diego Padres organizations (1).
Active Midwest League–Major League Baseball affiliations appear in bold.