Międzyrzec Podlaski [mʲɛnˈd͡zɨʐɛt͡s pɔdˈlaskʲi] (Latin: Meserici) is a town in Biała Podlaska County, Lublin Voivodeship, Poland, with the population of 17,102 inhabitants as of 2014[update].

The first official mention of Międzyrzec Podlaski as a town dates back to 1434, or (alternatively) 1455 and 1477 according to different historical sources.

Międzyrzec quickly developed: in 1486, a Roman Catholic church was built here, and town's owner, Jan Nassutowicz, received permission for fairs.

During the Swedish invasion of Poland, the town was ransacked and burned by Swedes, who returned in 1706 and 1708, during the Great Northern War.

On 16 November 1918, German troops committed a massacre of some 44 Poles, members of the Polish Military Organisation and civilians.

German occupation ended on 17 November 1918, and the town was reintegrated with Poland, which regained independence a few days earlier.

[6] On 25–26 August 1942, the first mass deportation of Jews from Międzyrzec took place with around 10,000 prisoners forcibly put on 52 cattle cars (shipment #566 according to the German inventory) and sent to Treblinka extermination camp.

The German occupiers also operated a forced labour subcamp of the Stalag 366 prisoner-of-war camp, in which Italian POWs were held.

Międzyrzec Podlaski is referred to by various names in different languages including Yiddish: מעזריטש Mezri'tsh, Latin: Meserici, Belarusian: Міжрэчча, German: Meseritz, Latvian: Meņdzižeca Podlaska, Lithuanian: Palenkės Mendzyžecas, and Ukrainian: Межиріччя.