At age three, she was a dual Classic winner in France and Britain, then went on to win the Breeders' Cup Mile in America.
Miesque was bred in Lexington, Kentucky by Flaxman Holdings, the breeding operation of shipping tycoon Stavros Niarchos.
Competing against colts and older horses she added wins in the Prix Jacques le Marois and the Prix du Moulin but was defeated by the British filly Milligram in the Queen Elizabeth II Stakes.
Miesque achieved international stardom when she defeated a talented field of mostly male horses in the prestigious 1987 Breeders' Cup Mile, in the process setting a Hollywood Park course record of 1:324⁄5.
Her powerful performance earned her the 1987 Eclipse Award for Outstanding Female Turf Horse.
She returned to the U.S. to defend her Breeders Cup title at Churchill Downs in Kentucky and once again was up against a very strong field of older males including Warning, Belmont Stakes winner Bet Twice and Steinlen.
Despite the fierce competition, the filly won the race by four lengths, making her the first ever back-to-back winner in Breeders Cup history.
Recently, her maternal-line descendant Loves Only You won the 2021 Breeders' Cup Filly & Mare Turf.
The annual Prix Miesque at the Hippodrome in Maisons-Laffitte, Yvelines is held in her honor.