As a third baseman for the Yankees, Andújar finished second in 2018 American League Rookie of the Year voting behind Shohei Ohtani.

Following a season-ending injury to Gleyber Torres in June, he was promoted to the Scranton/Wilkes-Barre RailRiders of the Triple-A International League.

[9] Following the conclusion of the RailRiders' season, where Andujar had batted .317 with nine home runs and 30 RBIs in 58 games, the Yankees promoted him to the major leagues on September 16.

[10] Andújar began the 2018 season with Scranton/Wilkes-Barre, but was promoted to the major leagues on April 1 after an injury to Billy McKinney.

Andújar joined Joe DiMaggio and Mickey Mantle as the only Yankees to ever have 7 consecutive games with an extra base hit under the age of 24.

On May 4, Andujar hit his first career walk-off, an RBI single to secure a 7-6 win over the Cleveland Indians.

[16] He was diagnosed with a partial glenoid labrum tear, but chose to rehabilitate the injury rather than undergo surgery.

[23] On March 22, 2022, Andújar signed a $1.3 million contract with the Yankees, avoiding salary arbitration.

The Pirates signed Andújar to a one-year contract worth $1.525 million, avoiding salary arbitration, on November 18.

[29] The Pirates designated Andújar for assignment on January 20, 2023, after the signing of Andrew McCutchen was made official.

[40] He ultimately played in 75 games for Oakland, slashing .285/.320/.377 with four home runs, 30 RBI, and three stolen bases.

On August 28, manager Mark Kotsay announced that Andújar would undergo season–ending core muscle surgery.

[1] In March 2022, Andújar was robbed at gunpoint at his farm in San Cristóbal, Dominican Republic.