Miguel Cotto vs. Canelo Álvarez was a professional boxing match contested on November 21, 2015, for the WBC, The Ring and TBRB middleweight championship.

[3] Having made one defence of the middleweight championship he had won from Sergio Martinez, dominating former titleholder Daniel Geale, Miguel Cotto agreed to face former Unified Light middleweight champion Canelo Álvarez with the winner set to face WBC "interim" champion Gennady Golovkin.

Cotto then stated publicly that the reason the WBC stripped him of his title was because he refused to pay their sanctioning fees, which he believed to be excessive.

The co-feature of the fight saw Takashi Miura, defending the WBC world super featherweight title for the fifth time against Francisco Vargas, who was the mandatory challenger.

Miura would then have success with a straight left and body punches, opening a sizable cut under Vargas' right eye.

Both fighters showed iron chins, with Cotto repeatedly coming back after hard shots to the head.

The scorecards at the end of the night were highly controversial as they did not show the competitiveness of the fight, with many boxing pundits having Álvarez winning by a round or two, others called it a draw.

[16] HBO's unofficial scorer Harold Lederman scored the fight 117–111 for Álvarez, as did Doug Fischer of The Ring.