In 1855 he took up arms in Zamora, Michoacán during the Ayutla Revolution in support of the liberal forces with the aim of overthrowing the dictatorship of Antonio López de Santa Anna and was promoted to colonel after these conflicts.

Regarding this, Ernesto de la Torre comments: Negrete, with 1,200 soldiers and two field and mountain batteries, defended the heights and was the one who bore the brunt of the battle and to whom the victory was due, heroically aided by all his companions, accurately led by General Ignacio Zaragoza.Around 1863, and being governor of the State of Puebla, before the advance of the French troops, he and Jesús González Ortega were entrusted with the defense of the Siege of Puebla.

The first was to support Julio Chávez López in Texcoco who had launched the Manifesto in Chalco to all the oppressed and poor of Mexico and the universe.

Due to the unexpected death of Juárez, Sebastián Lerdo de Tejada assumed the presidency and the Noria rebellion halted afterwards.

In 1879, during the Porfiriato, Negrete published a manifesto addressed to the nation, criticizing and accusing Porfirio Díaz of betraying the Constitution of 1857.

[3] I fought the administration of Mr. Juárez despite the great respect for that high figure, whose fame has been consecrated by history, when his continuation in government had broken the support of public opinion and the foundation of the national will.

[4] On December 5, 2007, in the Plenary Hall of the Legislative Assembly of the Congress of Puebla, the name of the general poblano "Miguel Negrete" was written in gold letters.