He has previously played in Major League Baseball (MLB) for the New York Yankees and Pittsburgh Pirates, and in NPB for the Tokyo Yakult Swallows.

[1][2] He made his professional debut that season at 17 years of age with the Dominican Summer League Yankees, and was 0–2 with a 1.42 ERA with an 0.926 WHIP in 57 innings in 14 starts.

[3][4] He played in 2016 with the Gulf Coast Yankees, and was 1–2 with a 2.87 earned run average (ERA) in 31+1⁄3 innings over nine games (six starts).

[10][11] On January 24, 2021, the Yankees traded Yajure, Roansy Contreras, Maikol Escotto, and Canaan Smith-Njigba to the Pittsburgh Pirates for pitcher Jameson Taillon.

Pitching in relief against the Cincinnati Reds, he surrendered two earned runs on two hits and a walk with two strikeouts in three innings of work.

[17] He spent the 2023 season split between the Single–A San Jose Giants, High–A Eugene Emeralds, and Triple–A Sacramento River Cats.

[20] On December 6, 2024, Yajure signed with the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball.