[3] Shoulder and knee injuries (the latter prompting two surgeries) forced her off the pro tour for years, long enough that she went back to school,[4] graduating with a doctorate at the National University of Physical Education and Sport in December 2016.

At the Internationaux de Strasbourg, she surrendered a lead in the singles semifinals against Dominika Cibulková, eventually losing the match in three sets.

[5] She showed more consistency in the doubles, winning the tournament and her first WTA title with compatriot Raluca Olaru in straight sets against Nadiia Kichenok and Anastasia Rodionova.

In the grass-court season, Buzărnescu reached the quarterfinals of the Nature Valley Open in Nottingham, losing to Naomi Osaka.

In August, Buzărnescu captured her first WTA Tour singles title winning in San Jose with a straight-sets victory over Maria Sakkari in the final.

Later in August, she played Elina Svitolina once more in the second round of the Rogers Cup in Montreal but suffered a serious ankle injury and was forced to retire.

[8] Seeded 25th at the Australian Open, she lost her first-round match to seven-time Grand Slam winner, two-time finalist, and former world No.

[12] Seeded fourth at the Abierto Mexicano in Acapulco, she won her first match of the season by beating Daria Gavrilova in the first round.

[17] Partnering Fanny Stollár, Buzărnescu won the doubles title at the 2021 Budapest Grand Prix, defeating Aliona Bolsova and Tamara Korpatsch in the final.

[19] Playing at the 2022 Wimbledon Championships, she entered the main draw by replacing Leylah Fernandez, and defeated qualifier Nastasja Schunk, in the first round,[20] before losing to 11th seed Coco Gauff.

[21] Buzărnescu recorded wins over Elisabetta Cocciaretto[22] and Yuan Yue[23] to reach the quarterfinals at the 2022 Swedish Open where she lost to Viktoriya Tomova.

[25][26] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.