He is first mentioned in a document from 1509 in which the Council of the Prayer accepted his painting of St. John the Baptist for the Rector's Palace, Dubrovnik.

He later formed a joint trading business with his brother Jacob, but in 1514 they got into trouble, and Mihajlo was forced to flee from Dubrovnik.

In 1518, together with Pierre Giovanni, he was given the task of completing the polyptych for the altar of Saint Joseph in the cathedral, which Nikola Božidarević had started, but Hamzić died suddenly before he could finish.

Only two of his paintings have survived: The baptism of Christ in Rector's Palace and the Triptych for the Lukarević family in the Dominican monastery in Ragusa.

[1] Hamzić brought lyrical accents and somewhat naïve pictorial elements (birds and deer), into a serious and strictly imagined landscape.