In 1992, Kanno made her debut as a member of a group called Sakurakko Club after passing the orientation for the TV variety show Sakurakko Kurabu.

As a member of the Sakura Gumi, she started to participate actively for the group's second single DO-shite.

Afterwards, she continued to take on lead roles in several TV and live stage dramas.

In 2005, she featured in the Fuji TV show Burogu Taipu as a regular.

On 2 April 2013, Miho Kanno registered her marriage with fellow actor Masato Sakai in Tokyo.