He is best known for his work for DC Comics in the 1980s inking the artwork of such artists as George Pérez, Greg LaRocque, Keith Giffen, and Jim Aparo.

DeCarlo has worked on various titles including Atari Force, Cartoon Network Block Party, Crisis on Infinite Earths, Fantastic Four, and Simpsons Comics as well as adaptations of the Warner Bros. stable of cartoons including Looney Tunes, Animaniacs, Pinky and the Brain and Superman & Bugs Bunny.

[4] DeCarlo inked the penciled artwork of George Pérez on "The Judas Contract" storyarc in Tales of the Teen Titans with Giordano.

[5] Bongo Comics Group's Radioactive Man series received an Eisner Award in 2002 for "Best Humor Publication" while DeCarlo was one of the artists.

[11] DeCarlo illustrated the covers to the DC Heroes role-playing game adventures Deadly Fusion (1990)[12]: 46  and The Law of Darkness (1990).