He was considered a four-star recruit by Rivals.com and was rated as the seventh-best all-purpose running back prospect in the nation.

[3] As a true freshman in 2009, Gillislee played in 13 games, rushing for 267 yards on 31 carries with two touchdowns.

[13] After not contributing in the 2014 regular season and being on injured reserve, on September 5, 2015, Gillislee was released by the Dolphins.

[19] During his first game as a member of the Bills, in Week 13 against the Houston Texans, Gillislee broke away for a 30-yard gain, his personal longest rush as an NFL player at the time.

[25] After Karlos Williams was released by the Bills after showing up out of shape, he stepped in and took the role of backup running back.

[28] On April 18, 2017, the New England Patriots extended a two-year, $6.4 million offer sheet to Gillislee, giving the Bills five days to match.

[30] In order to sign him, the Patriots had to give up a 2017 fifth round draft pick (which the Bills used to select Matt Milano).

In the game, Gillislee scored the first points of the 2017 NFL season with his first rushing touchdown in the first quarter.

Without Gillislee, the Patriots reached Super Bowl LII where they lost by a score of 41-33 to the Philadelphia Eagles.

[36] On September 1, 2018, Gillislee was released by the Patriots after being passed on the depth chart by veteran Jeremy Hill.