Mike James (born April 13, 1991) is a former American football running back who played for the Tampa Bay Buccaneers and Detroit Lions.

James attended Ridge Community High School in Davenport, Florida, where he played for the Bolts football team.

[3] The next year he was released by the Buccaneers on September 29, then signed to the practice squad on October 1, and promoted to the active roster on December 26, 2015.

James says cannabis helped him overcome his own painkiller addiction while recovering from a severe ankle injury sustained in 2013.

[14] In 2018, after failing a drug test the previous year, James filed a therapeutic use exemption (TUE) with the NFL to allow him to use cannabis.

[16][17] James was featured in the CNN documentary Weed 4 discussing his use of cannabis as an alternate pain reliever and his push for the NFL to allow its use.