Keane is a three-time Stanley Cup champion, having won with the Montreal Canadiens in 1993, Colorado Avalanche in 1996, and the Dallas Stars in 1999.

He then joined the major junior ranks in the Western Hockey League (WHL) with the Moose Jaw Warriors.

Undrafted out of junior, Keane signed as a free agent on September 25, 1985, with the Montreal Canadiens and started his NHL career in 1988.

Keane was subject to media scrutiny after speaking to Mathias Brunet of La Presse (a French language newspaper).

[4] During the 1995–96 NHL season, Keane was traded along with Patrick Roy to the Colorado Avalanche in exchange for Jocelyn Thibault, Andrei Kovalenko, and Martin Ručinský.

Keane's number 12 jersey was retired February 12, 2011, when the Manitoba Moose took on the San Antonio Rampage at Bell MTS Place.