He played in Major League Baseball (MLB) for the Texas Rangers, Houston Astros, Minnesota Twins, Milwaukee Brewers, Florida Marlins from 2000 through 2008, and 2010.

He collected his first major league hit with a third-inning single off Twins pitcher Brad Radke.

[2] He played for the Rangers until February 5, 2004, when he was traded to the New York Yankees for minor leaguer Jose Garcia.

In 2005, Lamb saw more playing time due to regular first baseman Jeff Bagwell's injury.

[5] On December 14, 2007, Lamb signed a two-year, $6.6 million deal with the Minnesota Twins that included a club option for 2010.

[12] He spent the entire 2009 season with the Triple-A Buffalo Bisons, batting .264 with five home runs and 53 RBI in 119 games.