McShane has also been involved in several Disney productions, including Tom and Huck (1995), the television series Brotherly Love (1995–97), Tower of Terror (1997), and A Bug's Life (1998).
McShane voiced Marlon, Caracticus P. Doom and various other characters in Cosgrove Hall Films's Avenger Penguins (1993–94), Gareb in Todd McFarlane's Spawn (1997–99), and Quosmir in Dave The Barbarian (2004–05).
He also co-starred with Sir John Gielgud, Emily Watson and Rosemary Harris in "A Summer's Day Dream" for BBC "Performance" series.
In 1997 he appeared in Tower of Terror, a TV movie starring Steve Guttenberg and Kirsten Dunst based on the Disney attraction, as "Q".
McShane also appeared with Dunst in the 1999 comedy film Drop Dead Gorgeous, playing a quick-tempered beauty pageant judge who serves as caretaker for his learning disabled brother.
He also provided the voice of Shalulu in Disney's redub of Castle in the Sky, and Baron Rakan Harkonnen in the 2001 strategy game Emperor: Battle for Dune.
McShane appeared as the voice of Audrey II (as well as playing a number of peripheral characters) in the London revival of Little Shop of Horrors at the Menier Chocolate Factory in Southwark between December 2006 and February 2007.
In 2008, McShane appeared as a guest performer in Paul Merton's Impro Chums, a live improv show, and was asked to join the permanent company for three UK tours, and is still ongoing with the group.
In February 2013, Mike created the role of Louis B. Mayer in the new musical "The Tailor Made Man" at The Arts Theatre in London's West End, garnering rave reviews.