He was the head coach of the Cleveland Browns from 2014 to 2015, and has also served as the defensive coordinator for the Buffalo Bills, New York Jets, and Green Bay Packers.

The head coach was his father, Mike Pettine Sr., who is renowned in Pennsylvania for compiling a record of 326–42–4 in 33 seasons and winning four state championships.

The TV show consisted of two separate hours and followed the team behind the scenes during the 1999 season and highlighted the rivalry between North Penn and Central Bucks West.

[7] On December 2, 2018, the Packers fired McCarthy after a 20–17 loss to the Arizona Cardinals at home, and he was replaced by interim head coach Joe Philbin.

On January 7, 2019, the Packers hired Matt LaFleur as their new head coach, who announced he would retain Pettine as defensive coordinator through the 2019 season.

In the 2020 NFC Championship Game, the Packers defense picked off quarterback Tom Brady three times, but also gave up a late first-half touchdown when Pettine called for cornerback Kevin King to cover receiver Scotty Miller one-on-one.