After submitting some sample pages of the Flash running, Wieringo was offered the penciling duties on Volume 2 of that series, on which he was paired with writer Mark Waid, and on which he rose to prominence in the industry, drawing all but two issues from #80–92 (Early Sept. 1993–July 1994), plus #0 (Oct.

[6] Wieringo followed this with a short run on Robin, another DC title, with writer Chuck Dixon, while concurrently penciling Marvel Comics' Rogue #1–4 (Jan.–April 1995),[4][7] a miniseries starring that X-Men superheroine.

[5] After having penciled the Spider-Boy #1 (April 1996) one-shot, which combined Spider-Man and Superboy as part of the Marvel Comics–DC Comics intercompany crossover series of one-shots Amalgam Comics,[8] Wieringo became the regular artist on Marvel's The Sensational Spider-Man, beginning with issue #8 (September 1996).

After Spider-Man, Wieringo's next major project was at Image Comics, where he reteamed with Dezago on their creator-owned fantasy series Tellos.

The last three issues were released by Gorilla Comics, a short-lived Image imprint co-founded by Wieringo and several other creators in 2000.

[11][12] Following the demise of the series, Wieringo also penciled one 13–page story in a post-series one-shot, Tellos: Maiden Voyage #1 (March 2001).

Wieringo returned to DC Comics for all but one issue of The Adventures of Superman #592–600 (July 2001 – March 2002), with writer Joe Casey.

The comics-hobbyist webzine Newsarama commented that the Waid–Wieringo run "was perhaps best known for fan outcry when Marvel announced that [it was] going to replace the team.

[14] Wieringo penciled the interior art on issues #1–5 and #8–10 of Friendly Neighborhood Spider-Man[15] and was the cover artist of #1–19 (December 2005 – June 2007).

[4] On August 12, 2007, Wieringo died of an aortic dissection at his home in Durham, North Carolina, at age 44.

The completed 48-page book, What If?—The Fantastic Four Tribute to Mike Wieringo, features, in addition to Wieringo's art, artwork by Arthur Adams, Paul Renaud, Stuart Immonen, Cully Hamner, Alan Davis, David Williams, Sanford Greene, Humberto Ramos, Skottie Young, Mike Allred, and Barry Kitson, and was released in June 2008.