[7] From 2000 till 2002, Zambidis defeated notable kickboxer Jenk Behic twice, Gürkan Özkan twice who outweighed Mike by over 50 lbs in two rare open-weight fights,[8] Kara Murat twice, Baris Nezif, Wanlop Sosathopan, Bakari Tounkara, Matteo Sciacca and Petr Polak.

[11] In 2003, promoter Tarik Solak arranged Zambidis' debut fight in Japan against 2002 World K-1 Max Champion Albert Kraus, whom he knocked out in the 2nd round.

In April 2005, Zambidis knocked out the popular Norifumi "Kid" Yamamoto with a right hook, in front of thousands of the Japanese kickboxer's fans.

[check quotation syntax] In addition to his many outstanding fights, the K-1 World MAX 2010 Final 16 match on October the 3rd, 2010 against Chahid Oulad El Hadj was notable as being one of the most exciting of his career.

In addition, as stated by ring side commentators "Sugar" Ray Sefo and Michael Schiavello, this contest was one by which a standard was set for other K-1 fights.

[21] He lost to Xu Yan by unanimous decision, suffering controversial knockdowns in rounds one and two as he received below blows in both occasions, at Hero Legends in Jinan, China on 3 January 2014.

In March 2019, returned to active action after 3.5 years off abstention for a professional boxing match vs Venezuelan Antonio Gomez.