As a freshman at the University of Illinois, Leshoure played sparingly collecting 126 yards on 35 carries.

[1] and capping off the season by scoring three touchdowns in the Illini's 38-14 victory over Baylor in the 2010 Texas Bowl.

Leshoure was taken with the 57th overall pick in the second round of the 2011 NFL draft by the Detroit Lions.

[4] On August 8, 2011, Leshoure tore his Achilles tendon in practice after a collision with Cliff Avril, and missed his entire rookie season.

[6] Leshoure had 26 carries for 100 yards and a touchdown, but the Lions lost 44–41 in overtime.