[3] In his senior season, he completed 154 passes for 2,069 yards and 22 touchdowns, winning a second straight state championship as the starting quarterback at Chandler.

[4][5] As a three-star recruit, Keene committed to play college football at the University of Central Florida (UCF).

[14] In the season opener against Purdue, Keene threw for four touchdowns and 366 yards, leading Fresno State to a 39–35 victory.

In the New Mexico Bowl, he threw for a career-high 380 yards and recorded four total touchdowns, being named the game's offensive MVP.

[22][23] On December 23, 2024, Keene transferred to the University of Michigan for his fifth and final season of college football in 2025, playing under head coach Sherrone Moore.