Mikey Post was born in Columbus, Ohio, but soon after his birth he and his family moved to Roswell, Georgia, where he lived for most of his life.

After high school, he attended the University of Georgia (UGA) and received his bachelor's degree in Management Information Systems Technology.

In 2013, Mikey announced via his Facebook fan page that he was struggling with his health after being diagnosed with amyotrophic lateral sclerosis (ALS).

Mikey later appeared in various feature films and also played the role of Wicket for the Star Wars nationwide tour in 2006 and in the Rose Parade on New Year's Day 2007.

He most notably appeared in the movie Bedtime Stories, starring Adam Sandler & Keri Russell, where he played the Angry Dwarf.